Although retroviral overexpression, as used in this study, is likely to lead to artificially high transcriptional expression of MN1 and the mutants, we found that AML patients with the highest MN1 expression had similar expression levels to our murine MN1-transduced cell lines with the lowest MN1 expression, suggesting that at least some of our cell lines are comparable to patient data (data not shown). This evidence concerns the gene MN1 and acute myeloid leukemia.