EDN1 and atrial fibrillation: In conclusion, besides the natriuretic peptides MR-proANP and Nt-proBNP and fibrinogen we identified novel candidate biomarkers reflecting vascular function, MR-proADM and C-terminal pro endothelin-1, and myocardial damage, TnI ultra, in relation to AF in the general population that may improve risk assessment in AF and merit prospective investigation in future studies.