In conclusion, besides the natriuretic peptides MR-proANP and Nt-proBNP and fibrinogen we identified novel candidate biomarkers reflecting vascular function, MR-proADM and C-terminal pro endothelin-1, and myocardial damage, TnI ultra, in relation to AF in the general population that may improve risk assessment in AF and merit prospective investigation in future studies. Here, NPPB is linked to atrial fibrillation.