IFNGR1 and hereditary elliptocytosis: In IFN-γR+/− (HE) mice kept in IVC cages, lactobacilli loads were approximately 1.7 log lower when compared to IFN-γR+/− (HE) and IFN-γR−/− (HO) mice in open cages (p<0.005; Fig. 5D), whereas Clostridium leptum levels were approximately one order of magnitude lower in IFN-γR+/− (HE) mice kept in open cages as compared to IFN-γR+/− (HE) animals in IVC and IFN-γR−/− (HO) mice in open cages (p<0.005 and p<0.05, respectively; Fig. 5G).