TGFB1 and neoplasm: Bronisz et al. [27] demonstrated that downregulation of mir-320 in mammary stromal fibroblasts reprograms the tumor microenvironment by activating a pro-oncogenic secretome, and interestingly, Yao et al. [28] reported that myofibroblast transdifferentiation from progenitor fibroblasts in response to TGF-β could be prevented using specific antisense inhibitors of miR-21.