In this present study we investigated the effect of hypoglycemia and hyperglycemia on three major classes of proteins: (i) the ligand VEGF and its receptors (VEGFR1, VEGFR2 and co-receptor Neuropilin-1), (ii) cell-cell adhesion proteins, (iii) cell to ECM adhesion proteins. Here, KDR is linked to Hyperglycemia.