TP53 and cancer: While, the canonical functions of p53 and NFκB are consistent with the co-occurrence of p53 inactivation and NFκB hyper-activation that is frequent in cancer [7], recent studies provided examples of positive cooperation between p53 and NFκB that would occur in specific cell types, such as antigen presenting cells or macrophages, and contribute to physiological responses, such as for example in the process of innate immunity and inflammation [12, 22, 23, 42].