In our search for candidate cancer-causing genes in frequently amplified regions, we focused on the gene Crem because it was amplified in 4/6 post PHx tumors and in 3/6 spontaneous tumors, and also due to its involvement in cancer [12, 13], including HCC metastasis [14], LR following PHx [15], circadian regulation [16, 31] and cytokine production [32]. Here, CREM is linked to cancer.