MMP13 and neoplasm: After adjustment for selected sociodemographic (age, gender, and risk habits) and clinicopathological parameters (tumor subsite, tumor differentiation, and pattern of invasion), positive MMP13 expression remained a significant prognostic factor for overall survival of OSCC (HRR = 3.850, 95% CI 1.234–12.010, P = 0.020, data not shown).