IL6 and type 2 diabetes mellitus: As shown in Table 1, the enriched pathways terms relevant with cell surface function, signal transduction, hormone regulation, cellular metabolism, and immune response were determined to be dysregulated in the progression of T2D, such as focal adhesion, MAPK signaling pathway, Prostaglandin Synthesis and Regulation, Eicosanoid Synthesis, Mitochondrial LC-Fatty Acid, Beta-Oxidation, Selenium Pathway, Fatty Acid Biosynthesis, Tryptophan metabolism, IL-6 signaling pathway, IL-7 signaling pathway, IL-1 signaling pathway, Inflammatory Response Pathway, and Complement and Coagulation Cascades.