PCDH19 and Speech apraxia: Participant 113 is a 26-month-old female with an ROH at Xq21.33-q22.1 including the PCDH19 and SRPX2 genes. PCDH19 encodes protocadherin 19 known to play a role in autism while the SRPX2 gene is associated with Rolandic epilepsy, intellectual disability, and speech dyspraxia [28].