The eosinophilic parameters that made major contributions for the segregation of the aGVHD patients from the patients without GVHD are shown in Figure 2b; these were higher absolute and relative numbers of eosinophils, raised levels of the activation marker CD69, the low-affinity IgE receptor CD23, and the adhesion molecules CD49d and CD54, as compared with the patients without GVHD. This evidence concerns the gene ITGA4 and graft versus host disease.