Mayer-Barber et al. [16] recently reported a rapid mortality of mice singly or double deficient for IL-1α and/or IL-1β, within 30–40 days post M. tuberculosis infection, although after low dose infection IL-1α or IL-1β single deficient mice succumbed 3–5 months after IL-1R1-deficient mice. Here, IL1B is linked to infection.