Interestingly, mice singly deficient for IL-1α or for IL-1β developed some granuloma with limited oedema, no necrosis and free alveolar space, thus a much less severe lung pathology than that seen in the absence of both IL-1α and IL-1β or of IL-1R1 at 5 weeks post-infection. The gene discussed is IL1R1; the disease is Granuloma.