IGHG3 and glomerulonephritis: On the other hand, there were no significant differences in serum ds-DNA titers, IgG3 levels or intraglomerular IgG3 deposition levels between sE-selectin Tg and wild-type MRL/lpr mice, in which IgG3 productions and depositions are regarded to play a critical role in the development of glomerulonephritis [49].