In this present study, we first demonstrated that E-selectin expression in glomeruli and small vessels gradually increases during the development of lupus nephritis and vasculitis in MRL/MpJ-lpr/lpr (MRL/lpr) lupus mice, and that this is accompanied by significant infiltration of the glomeruli and perivascular regions by CD68+ macrophages, CD4+ T cells and CD8+ T cells. Here, CD4 is linked to lupus nephritis.