The BCIRG 006 trial accrued early stage HER2 overexpressing breast cancer patients between April 2001 and March 2004 and compared three arms: AC-T (adriamycin, cyclophosphamide, and paclitaxel), AC-TH (adriamycin, cyclophosphamide, paclitaxel and trastuzumab), and TCH (docetaxel, cyclophosphamide, and trastuzumab). The gene discussed is ERBB2; the disease is breast carcinoma.