Thus, presumptive diagnosis of haemoglobinopathy in Nigeria should transcend routine alkaline electrophoresis and solubility test and should include evaluation of full blood count, red cell indices, iron studies and HPLC as a method suited for the identification and quantification of other Hb variants while DNA analysis for definitive diagnosis will be good to have. The gene discussed is GSTM1; the disease is hemoglobinopathy.