HOTAIR and gastrointestinal stromal tumor: HOX transcript antisense RNA (HOTAIR) is upregulated in a number of different cancers, including breast (Gupta et al., 2010), colorectal (Kogo et al., 2011), hepatocellular (Geng et al., 2011), and gastrointestinal stromal tumors (Niinuma et al., 2012).