PDLIM7 and carcinoma: Because the EBV-encoded transmembrane proteins LMP1 and LMP2A are capable of upregulating the cellular DNA methyltransferases DNMT1, DNMT3A, and DNMT3B, it was suggested that hypermethylation of CpG rich sequences, the so called CpG islands, is mediated by LMP1 or LMP2A in EBV-associated carcinomas (reviewed in Niller et al., 2012).