Later on, Koyama et al. (2000) demonstrated that CB plays an important role in glucose homeostasis in vivo, since dogs that have their CB resected presented lower arterial glucagon in basal conditions and reduced glucagon and cortisol levels during insulin-induced hypoglycemia, together with a marked decrease in endogenous hepatic glucose production in response to hypoglycemia, and with an increase in insulin sensitivity, independent of blood glucose level. Here, INS is linked to Hypoglycemia.