TNNT1 and mesothelioma: In our earliest studies examining what we later confirmed to be TnTs in mesothelioma, we performed standard exclusion assays using primary red blood cells (erythrocytes) or U937 lymphocyte (mononuclear) cells (Kultti et al., 2006; Rilla et al., 2008), but found no visual evidence of either pericellular zones or monocyte adhesion to TnT structures, indicating that TnTs were unlikely to harbor a significant amount of hyaluronan externally, also demonstrating that these entities are distinct from hyaluronan cables (Figure 7; Supplemental Figure S3).