REN and hypertensive disorder: Genetic and experimental models, such as mice which express human renin and angiotensinogen, renovascular hypertension (e.g., 2-kidney, 1-clip) and infusion of exogenous Ang II, are commonly used approaches to model human hypertension associated with increases in Ang II (Bean et al., 1979; Johns et al., 1996; Didion et al., 2000, 2002, 2005).