While the Ang II infusion model is most reflective of secondary forms of hypertension, it should be noted that a major target of antihypertensive therapy in essential hypertension in humans has been directed toward limiting Ang II signaling (e.g., ACE inhibitors and angiotensin receptor blockers) (Sica, 2010; Hanselin et al., 2011). The gene discussed is AGT; the disease is Hypertension.