In addition to hypertension, Ang II can produce endothelial dysfunction in a number of blood vessels (e.g., aorta, carotid artery, cerebral arterioles) in several species, including mice (Rajagoplan et al., 1996; Su et al., 1998; Didion et al., 2000, 2002, 2005; Wang et al., 2001; Didion and Faraci, 2003; Faraci et al., 2006; Guzik et al., 2007; Barhoumi et al., 2011). The gene discussed is AGT; the disease is endothelial dysfunction.