AGT and endothelial dysfunction: The combination of the Ang II model and genetic technologies has provided a wealth of information regarding genes that contribute to the development of hypertension and related vascular sequalae, including the role of oxidative stress and inflammatory cytokines as well as inflammatory cell types in promoting vascular hypertrophy and endothelial dysfunction (Bush et al., 2000; Wang et al., 2001; Ryan et al., 2004; Didion et al., 2005, 2009; Guzik et al., 2007; Schrader et al., 2007; Madhur et al., 2010; Barhoumi et al., 2011).