This is also complicated by the fact that the majority of studies in the literature examine single doses at single time points thus providing limited insight into the temporal development of hypertension and vascular dysfunction produced in response to Ang II (Bush et al., 2000; Ryan et al., 2004; Lee et al., 2006; Guzik et al., 2007; Didion et al., 2009; Barhoumi et al., 2011). The gene discussed is AGT; the disease is hypertensive disorder.