While we did not examine the contribution of oxidative stress to the impairment of endothelial function, previous studies, including our own, have shown that increases in oxidative stress, particularly Nox2-derived superoxide, contribute to endothelial dysfunction produced by Ang II (Rajagoplan et al., 1996; Didion et al., 2005, 2009; Schrader et al., 2007). The gene discussed is CYBB; the disease is endothelial dysfunction.