RORA and congestive heart failure: The nuclear receptor Retinoid-related orphan receptor-alpha (RORA), which is up-regulated in hippocampus of CHF mice, exerts a bi-directional regulation of astrocytes, being neuro-protective and anti-inflammatory, a pluripotent molecular player in constitutive and adaptive astrocyte physiology as adaptation after CHF development (Journiac et al., 2009).