Furthermore, there seem to be changes in axonal vesicular transport with subsequent maintenance of presynaptic function and regulation of synaptic plasticity and synaptic transmission in hippocampus after CHF induction as far as we found down-regulation in gene expression of Kif5b, responsible for axonal vesicular transport, and Gabrb2, responsible for regulation of synaptic transmission (Ma et al., 2009). The gene discussed is KIF5B; the disease is congestive heart failure.