SOD1 and amyotrophic lateral sclerosis: Using ALS models derived from human embryonic stem cells or transgenic mice, recent studies have demonstrated that both cell-autonomous and non-cell-autonomous processes contribute to neurodegeneration in SOD1-linked FALS (Nagai et al., 2007; Di Giorgio et al., 2007; Yamanaka et al., 2008; Wada et al., 2012).