IGF1 and Hyperglycemia: The deleterious effect of diabetes and hyperglycemia as cell death was previously well reported with underlying mechanisms of activation of p53 transcription factor, intrinsic cell death pathway and decreased IGF-I level due to increased blood glucose (Yamaguchi et al., 2001; Muranyi et al., 2003; Lechuga-Sancho et al., 2006).