SLC1A3 and Alzheimer disease: Furthermore, impairment in glutamate transporter GLT-1/GLAST were related to the neurodegenerative disorders like epilepsy, hypoxia/ ischemia, amyotrophic lateral sclerosis, Alzheimer's disease (AD), Parkinson disease (PD) and schizophrenia (Sims and Robinson, 1999; Danbolt, 2001).