The correlation between MnSOD and mPAP, PWP, LVEF combined with correlation between MnSOD and NT-proBNP, CRP, and UA may indicate a link among increased mitochondrial ROS generation, severity of HF, systemic and pulmonary hemodynamic, and the level of inflammation in DCM patients. This evidence concerns the gene SOD2 and familial dilated cardiomyopathy.