It should be noted that Damcott et al. also conducted a study to explore the SNPs across the promoter and coding regions of HNF-4α with T2D in 137 T2D, 139 prediabetes, and 342 healthy individuals; they only found that rs1884614 was significantly associated with T2D and the combined samples of T2D and prediabetes [20]. This evidence concerns the gene HNF4A and prediabetes syndrome.