LEP and diabetes mellitus: At univariate analysis, obestatin concentrations were positively correlated with leptin (r = 0.47; p <0.0001; Figure 1) age (r = 0.19 ; p = 0.01 ), heart failure (r =0.30; p = 0.003), and presence of metastasis (r = 0.39; p = 0.002), whereas a negative correlation with ghrelin (r = -0.59; p <0.0001; Figure 1), cholesterol (r = -0.45; p <0.0001), diabetes mellitus (r = -0.26; p = 0.002) and albumin (r = -0.21; p = 0.03) was found.