C-reactive protein (CRP), an acute-phase reactant produced primarily in the liver, has been shown to be a sensitive, systemic biomarker of inflammation.28 Several studies have consistently reported a positive association between smoking and CRP levels.29–33 A number of prospective studies have also described the association between circulating CRP levels and DM incidence, with some demonstrating an independently positive association,34–36 while others show no association.25,26,37,38. This evidence concerns the gene CRP and diabetes mellitus.