LEP and diabetes mellitus: Findings of previous studies investigating the association of both biomarkers individually with DM have been equivocal: independent positive associations with the disease of either leptin or CRP were reported in some studies22–24,34–36,66 but not all.25–27,37,38 These inconsistencies may be due in part to variations in the potential confounders considered among studies, in addition to differences in population characteristics.