SH-SY5Y cell treated by neurotoxin, such as β-amyloid46 and α-synuclein47, was widely investigated by using optical microscopy to evaluate the toxic effects of the neurotoxin, and further linking the response of the SH-SY5Y cell to the in vitro neuronal model of human diseases such as Alzheimer's and Parkinson's disease. This evidence concerns the gene PPIB and Parkinson disease.