Specifically CD133 + CXCR4+ cancer cells had a high metastatic capacity in liver metastases of colorectal tumors [25], metastatic pancreatic cancers [26], while overexpression of CD133, CD44v6 and human tissue factor was associated with pancreatic carcinoma metastasis [27]. This evidence concerns the gene PROM1 and familial pancreatic carcinoma.