The insulin receptor (INSR) is targeted by nine drugs of which eight are categorized in DrugBank as antidiabetic and/or hypoglycemic agents and the ninth, Mecasermin, is an insulin-like growth factor used for long-term treatment of growth failure in children with severe primary IGF-1 deficiency [28]. Here, INSR is linked to hyperinsulinemic hypoglycemia, familial, 4.