For example, association of variations in TTN with cardiomyopathy (Herman et al. 2012), ITPR2 with renal carcinoma (Wu et al. 2011), etc. Interestingly, there was a significant enrichment of trace amine receptor genes (TAAR2, TAAR3, and TAAR5), which are a family of G protein-coupled receptors known to bind endogenous biogenic amines and affect behavioral phenotypes (Keller and Vosshall 2008; Nei et al. 2008). This evidence concerns the gene ITPR2 and cardiomyopathy.