TP53 and malignant peripheral nerve sheath tumor: Mesenchymal glioblastoma multiforme (GBM), which is thought to stem from similar biomolecular pathways as malignant peripheral nerve sheath tumors (MPNST) including loss of neurofibromin (NF1) and TP53 function [6, 7], also shows increased prevalence of disease in men [8, 9].