We and others previously identified p53 as an important component of PAH-induced transcriptional responses in human cell lines and in vivo (Hamouchene et al. 2011; Hockley et al. 2006, 2008; Labib et al. 2012; Malik et al. 2012, 2013). The gene discussed is TP53; the disease is pulmonary arterial hypertension.