CDH1 and metastatic malignant neoplasm in the lymph nodes: Next, we investigated the relationship between E-cadherin expression and clinicopathological features of GC, and found that downregulated E-cadherin was associated with depth of invasion (P = 0.046), lymph node metastasis (P = 0.013), and TNM stage (P = 0.035), but not with other clinicopathological factors including sex, age, or differentiation (Table 1).