So, ubiquitin-conjugating enzyme E2L3 (UBE2L3), which ubiquitylates p105 for its degradation, tumor necrosis factor alpha-induced protein 3 (TNFAIP3, also known as A20), an ubiquitin-editing enzyme with determines NF-κB activity or TNFAIP3-interacting protein (TNIP1) which inhibits TNF-induced NF-κB -dependent gene expression have genetic variants associated with several autoimmune diseases [14]. This evidence concerns the gene TNFAIP3 and autoimmune disease.