Among them, several genes in the NF-κB pathway are associated with two or more immune-mediated diseases, such as inflammatory bowel disease (REL, TNFAIP3 and NFKB1), psoriasis (REL, TNFAIP3, NFKB1 and TNIP1), coeliac disease (REL and TNFAIP3), rheumatoid arthritis (REL and TNFAIP3), type 1 diabetes (T1D) (TNFAIP3), systemic lupus erythematous (SLE) (TNFAIP3 and TNIP1), multiple sclerosis and primary biliary cirrhosis (NFKB1) (Table 1). The gene discussed is TNFAIP3; the disease is rheumatoid arthritis.