Phospholipase Cβ 1 (PLC): The nuclear form of this enzyme is an important checkpoint that controls progression through the G1 phase, its activation depends on type 1 insulin-like receptor (IGF-R) and monoallelic deletions seem to be associated with aggressive disease both for patients with AML and patients with preleukemic myelodysplastic syndromes [108]. Here, IGF1R is linked to acute myeloid leukemia.