NFE2L2 and myelofibrosis: Accordingly, taken into account that chronic inflammation with ROS accumulation might induce an altered redox balance of pivotal significance for stem cell mobilization in myelofibrosis, we speculated if oxidative and anti-oxidative stress genes might be deregulated in MPNs with particular attention to the Nrf2 gene which plays such a central role in the regulation of hematopoietic stem cell (HSC) function.