As shown in Figure 3, the sensitivities of tumor markers were higher at the time of diagnosis of vascular invasion than at the time of initial treatment: 64.9% for AFP, 67.7% for DCP, and 47.4% for AFP-L3 at the diagnosis of vascular invasion when cut-off values of 100 ng/mL, 100 mAU/mL, and 15% were adopted, respectively. This evidence concerns the gene AFP and neoplasm.