The aim of this study was therefore to examine the expression of pIgR, and its prognostic impact, in primary tumours and paired lymph node metastases from a consecutive cohort of patients surgically treated with pancreaticoduodenectomy (PD) for pancreatic and periampullary adenocarcinoma (n = 175). This evidence concerns the gene PIGR and periampullary adenocarcinoma.