Mean titers of PR3-ANCA ELISA were significantly higher in PSC (PSC 14.9 CU, AIH-PSC 22.3) compared to controls (p<0.0001): AIH 6.4 CU, AIH-PBC 3.7 CU, PBC 2.7 CU, HCV 2.1 CU, HBV 2.7 CU, healthy controls 4.4 CU (Figure 2). This evidence concerns the gene PRTN3 and primary biliary cholangitis.