Other serological biomarkers are used for the diagnosis of AIH (ANA, F-actin, ASMA [33]) and PBC (i.e. AMA, gp210, sp100) [34], [35], however, apart from aANCA by IIF, which can also be seen in AIH, no simple serological test is currently available to alert the clinician to possible PSC. This evidence concerns the gene SP100 and autoimmune hepatitis.