During myocardial ischemia or reperfusion, the expression of many genes such as c-fos, c-jun, junB, Egr-1, and HSP70 is upregulated [23], [24], and some of them are considered to be involved in the endogenous cardioprotection against myocardial ischemia/reperfusion injury. The gene discussed is FOS; the disease is myocardial ischemia.