EPAS1 and malignant colon neoplasm: These researchers also demonstrated divergent cellular functions for HIF-α isoforms in SW480 colon cancer cells: the selective knockdown of HIF-1α resulted in lower rates of proliferation and migration in vitro, whereas the selective knockdown of HIF-2α exerted no effect on cellular proliferation in vitro but doubled the colony formation in soft agar assays [10].