As can be observed in Figure 5B, the HIF-1α- or HIF-2α-depleted colon cancer cells exhibited a decrease in tumorigenic activity in the grafted mice compared with the controls; however, this trend was not observed with the RKO cells, in which HIF-1α silencing did not significantly inhibit tumorigenic activity. The gene discussed is EPAS1; the disease is malignant colon neoplasm.