The results shown in Figure 1 indicate that as expected, hypoxia (3% O2) induced the expression of both HIF-1α and HIF2-α in both normal (112CoN) and cancerous cells; however, under normoxic culture conditions (20% O2), only the colon cancer cells co-expressed both HIF-1α and HIF-2α, while the non-malignant 112CoN cells did not express these factors under normoxic conditions. Here, EPAS1 is linked to malignant colon neoplasm.