TPT1 and tuberous sclerosis: This includes i) the regulation of the GTPase activity of the Drosophila Ras homologue Rheb, a direct target of TSC1/2 tumor suppressors responsible for tuberous sclerosis [8], ii) the stabilization of the GDP form of the translational elongation factor eEF1A [11], and iii) progression through cytokinesis by a mechanism that involves phosphorylation of TCTP by the polo-like kinase and, consequently, reduction of the microtubule-stabilizing activity of TCTP [12],[13].