In addition, release of numerous TH1/TH2-specific inflammatory mediators, such as interleukin (IL) types IL-4, IL-5, IL-6, IL-12p70, IL-13, interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) has been demonstrated in patients with AD [9], [10]. The gene discussed is TNF; the disease is Alzheimer disease.