On day 14, no obvious differences in the levels of IL-6 and TNF-α were observed between the nicotine group, methyllycaconitine group and myocarditis group (TNF-α.: Nicotine 130.50±8.20 pg/ml vs Methyllycaconitine 127.50±5.50 pg/ml vs Myocarditis 125.25±6.55 pg/ml, P>0.05, IL-6: Nicotine 34.25±2.20 pg/ml vs Methyllycaconitine 37.65±2.90 pg/ml vs Myocarditis 37.50±3.10 pg/ml, P>0.05). The gene discussed is TNF; the disease is myocarditis.