On day 7, compared to the myocarditis group, the levels of TNF-α and IL-6 were significantly lower in the nicotine group (TNF-α: Nicotine 133.75±8.42 pg/ml vs Myocarditis 160.60±8.75 pg/ml; IL-6: Nicotine 38.00±2.80 pg/ml vs Myocarditis 44.00±1.82 pg/ml, P<0.05) (Figure 4) and were higher in the methyllycaconitine group (TNF-α: Methyllycaconitine 200.25±8.73 pg/ml vs Myocarditis 160.60±8.75 pg/ml; IL-6: Methyllycaconitine 58.02±2.56 pg/ml vs Myocarditis 44.00±1.82 pg/ml, P<0.05) (Figure 4). Here, TNF is linked to myocarditis.