TRPV1 and neoplasm: Our present data suggest that the angiogenic effect of tumor-derived AEA on endothelial cells essentially involves TRPV1-mediated uptake of AEA, subsequently followed by activation of intracellular AEA receptors (Rozenfeld and Devi, 2008; Brailoiu et al., 2011; den Boon et al., 2012; Fowler, 2013) yielding the pro-angiogenic effect of this endocannabinoid.