Interestingly, in PGC-SCZ, support was found for one of the most consistently implicated gene sets in schizophrenia, a set comprised of brain-expressed genes that interact with the Fragile X mental retardation (FMRP) protein.3,6,7,15 While the biological implications of this are not yet understood, it is likely that improving knowledge of the protein interactome and of the constituent members of sets of proteins involved in brain function will improve our ability to move from patterns of association to pathogenesis. Here, FMR1 is linked to schizophrenia.