STAT3 and cancer: Besidespruning intratumoural blood vessels by inhibiting endothelial cell proliferation (via VEGFR2inhibition) and depleting pericytes (via PDGFR inhibition), sunitinib may have direct inhibitoryeffects on cancer cells (e.g. via STAT3 inhibition) as well as broader effects on a variety of host(non-malignant) cells (Xin et al, 2009).