EGFR and neoplasm: However, current systemic treatment for mCRC is still largely based on shot gun approaches (‘one-size-fits-all’), and most patients are treated empirically with fluoropyrimidine-based chemotherapy regimens with or without oxaliplatin or irinotecan and bevacizumab, while the EGFR-targeted monoclonal antibodies cetuximab and panitumumab are administered to patients with RAS wild-type tumours.