DES and heart disorder: Mutations in human IF genes have been linked to at least 94 different disease entities ranging from skin, hair and nail diseases (keratins, lamin A/C), eye disorders (keratins, vimentin, phakinin), degenerative disorders of the central and peripheral nervous system (glial fibrillary acidic protein, neurofilament proteins, peripherin, lamin A/C), premature aging syndromes (lamin A/C), lipodystrophy and metabolic syndromes (lamin A/C) to skeletal muscle and cardiac diseases (lamin A/C, desmin) [34, 41].